Dual stimuli-responsive nano-vehicles for controlled drug delivery: mesoporous silica nanoparticles end-capped with natural chitosan.

@article{Hakeem2014DualSN,
  title={Dual stimuli-responsive nano-vehicles for controlled drug delivery: mesoporous silica nanoparticles end-capped with natural chitosan.},
  author={Abdul Hakeem and Ruixue Duan and Fouzia Zahid and Chao Dong and Boya Wang and Fan Hong and Xiaowen Ou and Yongmei Jia and Xiaoding Lou and Fan Xia},
  journal={Chemical communications},
  year={2014},
  volume={50 87},
  pages={13268-71}
}
  • Abdul Hakeem, Ruixue Duan, +7 authors Fan Xia
  • Published 2014 in Chemical communications
  • DOI:10.1039/c4cc04383a
Herein, we report natural chitosan end-capped MCM-41 type MSNPs as novel, dual stimuli, responsive nano-vehicles for controlled anticancer drug delivery. The chitosan nanovalves tightly close the pores of the MSNPs to control premature cargo release under physiological conditions but respond to lysozyme and acidic media to release the trapped cargo.