Dual stem loops within the poliovirus internal ribosomal entry site control neurovirulence.

@article{Gromeier1999DualSL,
  title={Dual stem loops within the poliovirus internal ribosomal entry site control neurovirulence.},
  author={Matthias Gromeier and Birgit Bossert and Minetaro Arita and A. Nomoto and Eckard J Wimmer},
  journal={Journal of virology},
  year={1999},
  volume={73 2},
  pages={958-64}
}
In the human central nervous system, susceptibility to poliovirus (PV) infection is largely confined to a specific subpopulation of neuronal cells. PV tropism is likely to be determined by cell-external components such as the PV receptor CD155, as well as cell-internal constraints such as the availability of a suitable microenvironment for virus propagation. We reported previously that the exchange of the cognate internal ribosomal entry site (IRES) within the 5' nontranslated region of PV with… CONTINUE READING