Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite.

@article{Ramalhete2014DualstageTF,
  title={Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite.},
  author={C{\'a}tia Ramalhete and Filipa P. da Cruz and Silva Mulhovo and In{\^e}s J. Sousa and M. X. Fernandes and M. Prud{\^e}ncio and Maria-Jos{\'e} U. Ferreira},
  journal={Bioorganic \& medicinal chemistry},
  year={2014},
  volume={22 15},
  pages={
          3887-90
        }
}
Sixteen triterpenoids (1-16), previously isolated from the aerial parts of the African medicinal plant Momordica balsamina or obtained by derivatization, were evaluated for their activity against liver stages of Plasmodium berghei, measuring the luminescence intensity in Huh-7 cells infected with a firefly luciferase-expressing P. berghei line, PbGFP-Luccon. Toxicity of compounds (1-16) was assessed on the same cell line through the fluorescence measurement of cell confluency. The highest… Expand
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