Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) enhances tau expression.

  title={Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) enhances tau expression.},
  author={Wei Qian and Nana Jin and Jianhua Shi and Xiaomin Yin and Xiaoxia Jin and Shibao Wang and Maohong Cao and Khalid Iqbal and C X Gong and Fei Liu},
  journal={Journal of Alzheimer's disease : JAD},
  volume={37 3},
Microtubule-associated protein tau is found to be accumulated and aggregated in the brains of individuals with Alzheimer's disease and related tauopathies. Dual-specificity tyrosine-phosphorylation regulated kinase 1A (Dyrk1A) is overexpressed in Down syndrome and may play a critical role in the early onset of tau pathology in this disease. To investigate the effect of Dyrk1A on tau expression, we co-expressed different isoforms of tau with Dyrk1A in HEK-293FT cells and measured the mRNA and… CONTINUE READING
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