Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4

@article{Huang2010DualspecificityHD,
  title={Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4},
  author={Chengyang Huang and Yang Xiang and Yanru Wang and Xia Chong Li and Longyong Xu and Ziqi Zhu and Ting Zhang and Qingqing Zhu and Kejing Zhang and Naihe Jing and Charlie Chen},
  journal={Cell Research},
  year={2010},
  volume={20},
  pages={154-165}
}
Dimethylations of histone H3 lysine 9 and lysine 27 are important epigenetic marks associated with transcription repression. Here, we identified KIAA1718 (KDM7A) as a novel histone demethylase specific for these two repressing marks. Using mouse embryonic stem cells, we demonstrated that KIAA1718 expression increased at the early phase of neural differentiation. Knockdown of the gene blocked neural differentiation and the effect was rescued by the wild-type human gene, and not by a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 61 references

Similar Papers

Loading similar papers…