Dual specificity A-kinase anchoring proteins (AKAPs) contain an additional binding region that enhances targeting of protein kinase A type I.

@article{Jarnaess2008DualSA,
  title={Dual specificity A-kinase anchoring proteins (AKAPs) contain an additional binding region that enhances targeting of protein kinase A type I.},
  author={Elisabeth Jarnaess and Anja Ruppelt and Anne Jorunn Stokka and Birgitte Lygren and John D Scott and Kjetil Task{\'e}n},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 48},
  pages={33708-18}
}
A-kinase anchoring proteins (AKAPs) target protein kinase A (PKA) to a variety of subcellular locations. Conventional AKAPs contain a 14-18-amino acid sequence that forms an amphipathic helix that binds with high affinity to the regulatory (R) subunit of PKA type II. More recently, a group of dual specificity AKAPs has been classified on the basis of their ability to bind the PKA type I and the PKA type II isozymes. In this study we show that dual specificity AKAPs contain an additional PKA… CONTINUE READING