Dual roles of the transcription factor grainyhead-like 2 (GRHL2) in breast cancer.

@article{Werner2013DualRO,
  title={Dual roles of the transcription factor grainyhead-like 2 (GRHL2) in breast cancer.},
  author={Stefan Werner and Sabrina Frey and Sabine Riethdorf and Christian P. Schulze and Malik Alawi and Lea Kling and Vida Vafaizadeh and Guido Sauter and Luigi Maria Terracciano and Udo Schumacher and Klaus Pantel and Volker Assmann},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 32},
  pages={
          22993-3008
        }
}
Using a retrovirus-mediated cDNA expression cloning approach, we identified the grainyhead-like 2 (GRHL2) transcription factor as novel protooncogene. Overexpression of GRHL2 in NIH3T3 cells induced striking morphological changes, an increase in cell proliferation, anchorage-independent growth, and tumor growth in vivo. By combining a microarray analysis and a phylogenetic footprinting analysis with various biochemical assays, we identified the epidermal growth factor receptor family member… CONTINUE READING
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