Dual roles for the telomeric repeats in chromosomally integrated human herpesvirus-6

  title={Dual roles for the telomeric repeats in chromosomally integrated human herpesvirus-6},
  author={Tamae Ohye and Hidehito Inagaki and Masaru Ihira and Yuki Higashimoto and Koji Kato and Junko Oikawa and Hiroshi Yagasaki and Takahiro Niizuma and Yoshiyuki Takahashi and Seiji Kojima and Tetsushi Yoshikawa and Hiroki Kurahashi},
  booktitle={Scientific reports},
Approximately 1 percent of healthy individuals carry human herpesvirus-6 within a host chromosome. This is referred to as chromosomally integrated herpesvirus-6 (CIHHV-6). In this study, we investigated the chromosomal integration site in six individuals harboring CIHHV-6B. Using FISH, we found that HHV-6B signals are consistently located at the telomeric region. The proximal endpoints of the integrated virus were mapped at one of two telomere-repeat-like sequences (TRSs) within the DR-R in all… CONTINUE READING
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