Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication


Viruses interact with multiple host cell factors. Some of these are required to promote viral propagation, others have roles in inhibiting infection. Here, we delineate the function of the cellular factor PHF13 (or SPOC1), a putative HIV-1 restriction factor. Early in the HIV-1 replication cycle PHF13 increased the number of integrated proviral copies and… (More)
DOI: 10.1098/rsob.170115


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