Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication

@article{Hofmann2017DualRO,
  title={Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication},
  author={Stephan Hofmann and Sandra Dehn and Ramona Businger and Sebastian Bolduan and Martha Schneider and Zeger Debyser and Ruth Brack-Werner and Michael Schindler},
  journal={Open Biology},
  year={2017},
  volume={7}
}
Viruses interact with multiple host cell factors. Some of these are required to promote viral propagation, others have roles in inhibiting infection. Here, we delineate the function of the cellular factor PHF13 (or SPOC1), a putative HIV-1 restriction factor. Early in the HIV-1 replication cycle PHF13 increased the number of integrated proviral copies and the number of infected cells. However, after HIV-1 integration, high levels of PHF13 suppressed viral gene expression. The antiviral activity… 

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