Dual role of the Trps1 transcription factor in dentin mineralization.

  title={Dual role of the Trps1 transcription factor in dentin mineralization.},
  author={Maria Kuzynski and Morgan A. Goss and M. C. J. Bottini and Manisha Yadav and Callie G Mobley and Tony Winters and Anne Poliard and Odile Kellermann and Brendan Lee and J. L. Mill{\'a}n and Dobrawa Napierala},
  journal={The Journal of biological chemistry},
  volume={289 40},
TRPS1 (tricho-rhino-phalangeal syndrome) is a unique GATA-type transcription factor that acts as a transcriptional repressor. TRPS1 deficiency and dysregulated TRPS1 expression result in skeletal and dental abnormalities implicating TRPS1 in endochondral bone formation and tooth development. Moreover, patients with tricho-rhino-phalangeal syndrome frequently present with low bone mass indicating TRPS1 involvement in bone homeostasis. In addition, our previous data demonstrated accelerated… CONTINUE READING
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