Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.

@article{Suofu2017DualRO,
  title={Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.},
  author={Yalikun Suofu and Wei Li and Frederic G. Jean-Alphonse and Jiaoying Jia and Nicolas K Khattar and Jiatong Li and Sergei V. Baranov and Daniela Leronni and Amanda C Mihalik and Yanqing He and Erika Cecon and Vanessa L. Wehbi and Jinho Jay Kim and Brianna E Heath and Oxana V. Baranova and Xiaomin Wang and Matthew J Gable and Eric S. Kretz and Giulietta Di Benedetto and Timothy R. Lezon and Lisa M. Ferrando and Timothy M Larkin and Mara L. G. Sullivan and Svitlana Yablonska and Jingjing Wang and M Beth Minnigh and G{\'e}rald Guillaumet and Franck Suzenet and R. Mark Richardson and Samuel M. Poloyac and Donna B Stolz and Ralf Jockers and Paula A Witt-Enderby and Diane L Carlisle and Jean-Pierre Vilardaga and Robert Max Friedlander},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 38},
  pages={
          E7997-E8006
        }
}
G protein-coupled receptors (GPCRs) are classically characterized as cell-surface receptors transmitting extracellular signals into cells. Here we show that central components of a GPCR signaling system comprised of the melatonin type 1 receptor (MT1), its associated G protein, and β-arrestins are on and within neuronal mitochondria. We discovered that the ligand melatonin is exclusively synthesized in the mitochondrial matrix and released by the organelle activating the mitochondrial MT1… CONTINUE READING

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