Dual role of macrophage in tumor immunity.

@article{Tamura2018DualRO,
  title={Dual role of macrophage in tumor immunity.},
  author={Ryota Tamura and Toshihide Tanaka and Yohei Yamamoto and Yasuharu Akasaki and Hikaru Sasaki},
  journal={Immunotherapy},
  year={2018},
  volume={10 10},
  pages={
          899-909
        }
}
Macrophages are significant in immune responses, assuming a defensive role. In contrast, macrophages often cause undesirable changes. These reactions are processes by which macrophages express different functional programs in response to microenvironmental signals, defined as M1/M2 polarization. Tumor immunity has been acknowledged for contributing to the elucidation of the mechanism and clinical application in cancer therapy. One of the mechanisms for the refractoriness to cancer immunotherapy… CONTINUE READING

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