Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis

@article{Gould2006DualRO,
  title={Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis},
  author={Ty A. Gould and Helmus van de Langemheen and Ernesto J. Mu{\~n}oz-El{\'i}as and John D. Mckinney and James C. Sacchettini},
  journal={Molecular Microbiology},
  year={2006},
  volume={61}
}
The role of isocitrate lyase (ICL) in the glyoxylate cycle and its necessity for persistence and virulence of Mycobacterium tuberculosis has been well described. Recent reports have alluded to an additional role for this enzyme in M. tuberculosis metabolism, specifically for growth on propionate. A product of β‐oxidation of odd‐chain fatty acids is propionyl‐CoA. Clearance of propionyl‐CoA and the by‐products of its metabolism via the methylcitrate cycle is vital due to their potentially toxic… 
Role of the methylcitrate cycle in propionate metabolism and detoxification in Mycobacterium smegmatis.
TLDR
Deletion of the M. smegmatis prpDBC locus is shown to reduce but not eliminate MCL activity, suggesting that the marked attenuation of ICL1/ICL2-deficient M. tuberculosis in mice could be due to the accumulation of toxic propionyl-CoA metabolites, rather than inability to utilize fatty acids per se.
Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2
TLDR
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TLDR
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TLDR
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TLDR
It is found that lysine acetylation plays an important role in the modulation of central carbon metabolism in M. tb cultures and another regulatory mechanism of ICL1 is uncovered.
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TLDR
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Potential Inhibitors for Isocitrate Lyase of Mycobacterium tuberculosis and Non-M. tuberculosis: A Summary
TLDR
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A Novel Role of the PrpR as a Transcription Factor Involved in the Regulation of Methylcitrate Pathway in Mycobacterium tuberculosis
TLDR
It is shown that an M. tuberculosis prpR-deletion strain exhibits impaired growth in vitro on propionate as the sole carbon source, and the findings suggest that it plays a key role in regulating expression of enzymes involved in both glyoxylate and methylcitrate pathways.
Mycobacterium smegmatis GlnR Regulates the Glyoxylate Cycle and the Methylcitrate Cycle on Fatty Acid Metabolism by Repressing icl Transcription
TLDR
The findings reveal the GlnR-mediated repression of icl on fatty acid metabolism, which might be a general strategy of nutrient sensing and environmental adaptation employed by mycobacteria.
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TLDR
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TLDR
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TLDR
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