Dual role of S-nitrosocaptopril as an inhibitor of angiotensin-converting enzyme and a nitroso group carrier.

@article{Park1992DualRO,
  title={Dual role of S-nitrosocaptopril as an inhibitor of angiotensin-converting enzyme and a nitroso group carrier.},
  author={J. Park},
  journal={Biochemical and biophysical research communications},
  year={1992},
  volume={189 1},
  pages={
          206-10
        }
}
  • J. Park
  • Published 1992
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
The S-nitroso derivatives of captopril can act as an inhibitor of an angiotensin-converting enzyme in the presence of thiol such as glutathione. S-Nitrosocaptopril also rapidly transfers its nitroso moiety to a heme protein, which is presumably the responsible mechanism for the activation of guanylate cyclase. These results suggest that S-nitrosocaptopril may serve as an effective hypotensive agent. 
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