Dual reporter MESP1 mCherry/w-NKX2-5 eGFP/w hESCs enable studying early human cardiac differentiation.

@article{Hartogh2015DualRM,
  title={Dual reporter MESP1 mCherry/w-NKX2-5 eGFP/w hESCs enable studying early human cardiac differentiation.},
  author={Sabine C. den Hartogh and Chantal Schreurs and Jantine J. Monshouwer-Kloots and Richard P Davis and David A Elliott and Christine L Mummery and Robert Passier},
  journal={Stem cells},
  year={2015},
  volume={33 1},
  pages={56-67}
}
Understanding early differentiation events leading to cardiogenesis is crucial for controlling fate of human pluripotent stem cells and developing protocols that yield sufficient cell numbers for use in regenerative medicine and drug screening. Here, we develop a new tool to visualize patterning of early cardiac mesoderm and cardiomyocyte development in vitro by generating a dual MESP1(mCherry/w)-NKX2-5(eGFP/w) reporter line in human embryonic stem cells (hESCs) and using it to examine signals… CONTINUE READING
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