Dual renin-angiotensin system blockade at optimal doses for proteinuria.

  title={Dual renin-angiotensin system blockade at optimal doses for proteinuria.},
  author={Gozewijn Dirk Laverman and Gerjan Navis and Robert H. Henning and Paul E. de Jong and Dick de Zeeuw},
  journal={Kidney international},
  volume={62 3},
BACKGROUND The antiproteinuric effect of combining the angiotensin-converting enzyme (ACE) inhibitor lisinopril and the angiotensin II (Ang II) antagonist losartan was compared to that of the optimal antiproteinuric doses of monotherapy. METHODS To this purpose, lisinopril and losartan were studied in 9 nondiabetic renal patients with median proteinuria 4.5 g/day (95% CI, 3.5, 6.4), creatinine clearance of 80 mL/min (95% CI, 66, 96), and mean arterial pressure (MAP) of 102 mm Hg (95% CI, 93… CONTINUE READING


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