Dual regulatory switch confers tighter control on HtrA2 proteolytic activity.

Abstract

High-temperature requirement protease A2 (HtrA2), a multitasking serine protease that is involved in critical biological functions and pathogenicity, such as apoptosis and cancer, is a potent therapeutic target. It is established that the C-terminal post-synaptic density protein, Drosophila disc large tumor suppressor, zonula occludens-1 protein (PDZ… (More)
DOI: 10.1111/febs.12799

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