Dual regulatory role for thyroid-hormone receptors allows control of retinoic-acid receptor activity

@article{Graupner1989DualRR,
  title={Dual regulatory role for thyroid-hormone receptors allows control of retinoic-acid receptor activity},
  author={Gerhart Graupner and Ken N. Wills and Maty Tzukerman and Xiaokun Zhang and Magnus Pfahl},
  journal={Nature},
  year={1989},
  volume={340},
  pages={653-656}
}
BOTH thyroid hormone (T3) and retinoic acid signal essential steps in development, differentiation and morphogenesis. Specific nuclear receptors for these ligands have recently been cloned1-8. Previously we have noted a close homology between the DNA-binding domains of the ε-retinoic acid receptor (RAR-ε, also designated RAR-β), the thyroid hormone receptors and the oes-trogen receptor2,9. We have now found that RAR-ε is very efficient at inducing transcription from two distinct thyroid-hormone… CONTINUE READING

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