Dual regulation of the cardiac L-type calcium channel in L6 cells by protein kinase C.

Abstract

The role of protein kinase C (PKC) in the regulation of cardiac L-type Ca(2+) channel activity (LCC) was investigated in L6 rat neonatal myoblasts. Depolarization of fura-2 loaded cells with 140mM KCl activated a Ba(2+) influx pathway that was blocked by nifedipine and stimulated by (-) Bay K 8644. At least two splice variants of the alpha(1C) subunit of… (More)
DOI: 10.1016/j.ceca.2008.03.005

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