Dual regulation of neuronal morphogenesis by a δ-catenin–cortactin complex and Rho

@inproceedings{Martinez2003DualRO,
  title={Dual regulation of neuronal morphogenesis by a δ-catenin–cortactin complex and Rho},
  author={Maria Cruz Martinez and Tomoyo Ochiishi and Michael Majewski and Kenneth S. Kosik},
  booktitle={The Journal of cell biology},
  year={2003}
}
Delta-catenin is a neuronal protein that contains 10 Armadillo motifs and binds to the juxtamembrane segment of classical cadherins. We report that delta-catenin interacts with cortactin in a tyrosine phosphorylation-dependent manner. This interaction occurs within a region of the delta-catenin sequence that is also essential for the neurite elongation effects. Src family kinases can phosphorylate delta-catenin and bind to delta-catenin through its polyproline tract. Under conditions when… CONTINUE READING

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