Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis

@article{Hampton1997DualRO,
  title={Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis},
  author={Mark B. Hampton and Sten Orrenius},
  journal={FEBS Letters},
  year={1997},
  volume={414}
}
The induction of apoptosis in Jurkat T‐lymphocytes with 50 μM hydrogen peroxide was associated with caspase activation. Caspase activity was first detected 3 h after treatment, and the morphological features of apoptosis were apparent by 6 h. At higher concentrations of hydrogen peroxide there was no detectable caspase activity, and the cells died by necrosis. Cells treated with hydrogen peroxide were impaired in their ability to undergo Fas‐mediated apoptosis. This appeared to be the result of… Expand
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