Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis.

@article{Hampton1997DualRO,
  title={Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis.},
  author={Mark B Hampton and Sten Orrenius},
  journal={FEBS letters},
  year={1997},
  volume={414 3},
  pages={552-6}
}
The induction of apoptosis in Jurkat T-lymphocytes with 50 microM hydrogen peroxide was associated with caspase activation. Caspase activity was first detected 3 h after treatment, and the morphological features of apoptosis were apparent by 6 h. At higher concentrations of hydrogen peroxide there was no detectable caspase activity, and the cells died by necrosis. Cells treated with hydrogen peroxide were impaired in their ability to undergo Fas-mediated apoptosis. This appeared to be the… CONTINUE READING

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