Dual regulation of adipose triglyceride lipase by pigment epithelium-derived factor: a novel mechanistic insight into progressive obesity.

@article{Dai2013DualRO,
  title={Dual regulation of adipose triglyceride lipase by pigment epithelium-derived factor: a novel mechanistic insight into progressive obesity.},
  author={Zhiyu Dai and Weiwei Qi and Cen Li and Juling Lu and Yuling Mao and Yachao Yao and Lei Li and Ting Zhang and Honghai Hong and Shuai Li and Ti Zhou and Zhonghan Yang and Xia Yang and Guoquan Gao and Weibin Cai},
  journal={Molecular and cellular endocrinology},
  year={2013},
  volume={377 1-2},
  pages={123-34}
}
Both elevated plasma free fatty acids (FFA) and accumulating triglyceride in adipose tissue are observed in the process of obesity and insulin resistance. This contradictory phenomenon and its underlying mechanisms have not been thoroughly elucidated. Recent studies have demonstrated that pigment epithelium-derived factor (PEDF) contributes to elevated plasma FFA and insulin resistance in obese mice via the activation of adipose triglyceride lipase (ATGL). However, we found that PEDF… CONTINUE READING

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