Dual regulation of RA-RhoGAP activity by phosphatidic acid and Rap1 during neurite outgrowth.

@article{Kurooka2011DualRO,
  title={Dual regulation of RA-RhoGAP activity by phosphatidic acid and Rap1 during neurite outgrowth.},
  author={Takao Kurooka and Yasuchika Yamamoto and Yoshimi Takai and Toshiaki Sakisaka},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 8},
  pages={
          6832-43
        }
}
During neurite outgrowth, Rho small G protein activity is spatiotemporally regulated to organize the neurite sprouting, extension, and branching. We have previously identified a potent Rho GTPase-activating protein (GAP), RA-RhoGAP, as a direct downstream target of Rap1 small G protein in the neurite outgrowth. In addition to the Ras-associating (RA) domain for Rap1 binding, RA-RhoGAP has the pleckstrin homology (PH) domain for lipid binding. Here, we showed that phosphatidic acid (PA) bound to… CONTINUE READING

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