Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.

@article{Martinez1997DualPO,
  title={Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.},
  author={A. Marina Martinez and Mohammad Afshar and Fernando Tadeu Bueno Martin and Jean-claude Cavadore and J-C. Labb{\'e} and Marcel Dor{\'e}e},
  journal={The EMBO journal},
  year={1997},
  volume={16 2},
  pages={343-54}
}
A cyclin-dependent kinase (cdk)-activating kinase (CAK) has been shown previously to catalyze T-loop phosphorylation of cdks in most eukaryotic cells. This enzyme exists in either of two forms: the major one contains cdk7, cyclin H and an assembly factor called MAT-1, whilst the minor one lacks MAT-1. Cdk7 is unusual among cdks because it contains not one but two residues (S170 and T176 in Xenopus cdk7) in its T-loop that are phosphorylated in vivo. We have investigated the role of S170 and… CONTINUE READING

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