Dual personality of GABA/glycine-mediated depolarizations in immature spinal cord.

@article{JeanXavier2007DualPO,
  title={Dual personality of GABA/glycine-mediated depolarizations in immature spinal cord.},
  author={C Jean-Xavier and George Z. Mentis and Michael J. O'Donovan and Daniel Cattaert and Laurent Vinay},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 27},
  pages={11477-82}
}
The inhibitory action of glycine and GABA in adult neurons consists of both shunting incoming excitations and moving the membrane potential away from the action potential (AP) threshold. By contrast, in immature neurons, inhibitory postsynaptic potentials (IPSPs) are depolarizing; it is generally accepted that, despite their depolarizing action, these IPSPs are inhibitory because of the shunting action of the Cl(-) conductance increase. Here we investigated the integration of depolarizing IPSPs… CONTINUE READING

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