Dual oxidase 2 is essential for the toll-like receptor 5-mediated inflammatory response in airway mucosa.

@article{Joo2012DualO2,
  title={Dual oxidase 2 is essential for the toll-like receptor 5-mediated inflammatory response in airway mucosa.},
  author={Jung-Hee Joo and J L Ryu and Chang-Hoon Kim and Hyun Jik Kim and Mi-Sun Suh and Jin-Oh Kim and Seung Yeun Chung and S N Lee and Hwan Mook Kim and Yun Soo Bae and J. P. Yoon},
  journal={Antioxidants & redox signaling},
  year={2012},
  volume={16 1},
  pages={
          57-70
        }
}
AIMS Airway mucosa is constantly exposed to various airborne microbes, and epithelial host defense requires a robust innate immunity. Recently, it has been suggested that NADPH oxidase (NOX) isozymes serve functional roles in toll-like receptor (TLR)-mediated innate immune responses. However, the molecular mechanism between TLR and NOX-mediated reactive oxygen species (ROS) production in human airway mucosa has been poorly understood. RESULTS Here, we show that flagellin-induced ROS… CONTINUE READING
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