Dual-mode regulation of the APC/C by CDK1 and MAPK controls meiosis I progression and fidelity

Abstract

Female meiosis is driven by the activities of two major kinases, cyclin-dependent kinase 1 (Cdk1) and mitogen-activated protein kinase (MAPK). To date, the role of MAPK in control of meiosis is thought to be restricted to maintaining metaphase II arrest through stabilizing Cdk1 activity. In this paper, we find that MAPK and Cdk1 play compensatory roles to… (More)
DOI: 10.1083/jcb.201305049

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