Dual-modality imaging with 99mTc and fluorescent indocyanine green using surface-modified silica nanoparticles for biopsy of the sentinel lymph node: an animal study

@inproceedings{Tsuchimochi2013DualmodalityIW,
  title={Dual-modality imaging with 99mTc and fluorescent indocyanine green using surface-modified silica nanoparticles for biopsy of the sentinel lymph node: an animal study},
  author={Makoto Tsuchimochi and Kazuhide Hayama and Michio Toyama and Ichiro Sasagawa and Norio Tsubokawa},
  booktitle={EJNMMI research},
  year={2013}
}
BACKGROUND We propose a new approach to facilitate sentinel node biopsy examination by multimodality imaging in which radioactive and near-infrared (NIR) fluorescent nanoparticles depict deeply situated sentinel nodes and fluorescent nodes with anatomical resolution in the surgical field. For this purpose, we developed polyamidoamine (PAMAM)-coated silica nanoparticles loaded with technetium-99m (99mTc) and indocyanine green (ICG). METHODS We conducted animal studies to test the feasibility… CONTINUE READING

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