Dual-modality gene reporter for in vivo imaging.

  title={Dual-modality gene reporter for in vivo imaging.},
  author={P Stephen Patrick and Jayne Hammersley and Louiza Loizou and Mikko I Kettunen and Tiago B Rodrigues and De-en Hu and Sui-Seng Tee and Robin Hesketh and S Kathleen Lyons and Dmitry Soloviev and David Yestin Lewis and Silvio Aime and Sandra M Fulton and Kevin M Brindle},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 1},
The ability to track cells and their patterns of gene expression in living organisms can increase our understanding of tissue development and disease. Gene reporters for bioluminescence, fluorescence, radionuclide, and magnetic resonance imaging (MRI) have been described but these suffer variously from limited depth penetration, spatial resolution, and sensitivity. We describe here a gene reporter, based on the organic anion transporting protein Oatp1a1, which mediates uptake of a clinically… CONTINUE READING
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