Dual mechanisms of regulation of Na/H exchanger NHE-3 by parathyroid hormone in rat kidney.

@article{Fan1999DualMO,
  title={Dual mechanisms of regulation of Na/H exchanger NHE-3 by parathyroid hormone in rat kidney.},
  author={L Fan and Michael R Wiederkehr and Roberto Collazo and Huaqing Wang and L A Crowder and Orson W Moe},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 16},
  pages={11289-95}
}
Parathyroid hormone (PTH) is a potent inhibitor of mammalian renal proximal tubule sodium absorption via suppression of the apical membrane Na/H exchanger (NHE-3). We examined the mechanisms by which PTH inhibits NHE-3 activity by giving an acute intravenous PTH bolus to parathyroidectomized rats. Parathyroidectomy per se increased apical membrane NHE-3 activity and antigen. Acute infusion of PTH caused a time-dependent decrease in NHE-3 activity as early as 30 min. Decrease in NHE-3 activity… CONTINUE READING
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