Dual mechanisms of NF-kappaB inhibition in carnosol-treated endothelial cells.

@article{Lian2010DualMO,
  title={Dual mechanisms of NF-kappaB inhibition in carnosol-treated endothelial cells.},
  author={Kai-Cheng Lian and Jing-Jing Chuang and Chia-Wen Hsieh and Being-sun Wung and Guan-Da Huang and Ting-Yan Jian and Yung-Wei Sun},
  journal={Toxicology and applied pharmacology},
  year={2010},
  volume={245 1},
  pages={21-35}
}
The increased adhesion of monocytes to injured endothelial layers is a critical early event in atherogenesis. Under inflammatory conditions, there is increased expression of specific cell adhesion molecules on activated vascular endothelial cells, which increases monocyte adhesion. In our current study, we demonstrate a putative mechanism for the anti-inflammatory effects of carnosol, a diterpene derived from the herb rosemary. Our results show that both carnosol and rosemary essential oils… CONTINUE READING

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