Dual mechanisms of Ca2+ oscillations in hepatocytes.

  title={Dual mechanisms of Ca2+ oscillations in hepatocytes.},
  author={Ielyaas Cloete and Paula J. Bartlett and Vivien Kirk and Andrew P Thomas and James Sneyd},
  journal={Journal of theoretical biology},

Short-term high fat diet feeding of mice suppresses catecholamine-stimulated Ca2+ signalling in hepatocytes and intact liver

It is proposed that impaired Ca2+ signalling plays a key role in the earliest phases of the etiology of NAFLD, and is responsible for many of the ensuing metabolic and related dysfunctional outcomes at the cellular and whole tissue level.

Geometric singular perturbation analysis of the multiple-timescale Hodgkin-Huxley equations

We present a novel and global three-dimensional reduction of a non-dimensionalised version of the four-dimensional Hodgkin-Huxley equations [J. Rubin and M. Wechselberger, Giant squid–hidden canard:



Calcium signaling in liver.

Control of calcium oscillations by membrane fluxes.

The model predicts that the cell can be balanced at a point where small changes in the Ca(2+) load can move the cell into or out of oscillatory regions, resulting in the appearance or disappearance of oscillations.

Coordinated intercellular calcium waves induced by noradrenaline in rat hepatocytes: dual control by gap junction permeability and agonist

It is found that second messengers and [Ca2+]i rises in one hepatocyte cannot trigger Ca2+ responses in connected cells, suggesting that diffusion across gap junctions, while required for coordination, is not sufficient by itself for the propagation of intercellular Ca2+, waves.

Models of IP3 and Ca2+ oscillations: frequency encoding and identification of underlying feedbacks.

The ectopic expression of an IP3 binding protein has been used to decrease the rate of IP3 turnover experimentally, resulting in a dose-dependent slowing and eventual quenching of the Ca2+ oscillations, consistent with a model based on positive feedback of Ca2- on IP3 production.

Calcium signaling in the liver.

This article will review the machinery responsible for the formation of Ca(2+) signals in the liver, the types of subcellular, cellular, and intercellular signals that occur, the physiological role of Ca (2+) signaling in the Liver, and the role ofCa(2+) signaling in liver disease.