Dual mechanisms governing muscle cell death in tadpole tail during amphibian metamorphosis.

@article{Nakajima2003DualMG,
  title={Dual mechanisms governing muscle cell death in tadpole tail during amphibian metamorphosis.},
  author={Keisuke Nakajima and Yoshio Yaoita},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2003},
  volume={227 2},
  pages={246-55}
}
The tadpole tail, which is twice as long as the body, is induced to resorb completely by thyroid hormone within several days during the anuran metamorphosis. To investigate the underlying mechanism, we undertook two approaches. First, we examined the effect of dominant-negative thyroid hormone receptor (DNTR) on muscle cell death in vitro. The overexpression of DNTR suppressed the death of a tail-derived myoblastic cell line induced by thyroid hormone. Second, tadpole tails were injected with a… CONTINUE READING

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