Dual mechanism of Fas-induced cell death in neuroglioma cells: a role for reactive oxygen species.

@article{Jayanthi1999DualMO,
  title={Dual mechanism of Fas-induced cell death in neuroglioma cells: a role for reactive oxygen species.},
  author={Subramaniam Jayanthi and Salvador Ord{\'o}{\~n}ez and Michael T. Mccoy and Jean Lud Cadet},
  journal={Brain research. Molecular brain research},
  year={1999},
  volume={72 2},
  pages={158-65}
}
ApoI/Fas belongs to the tumor necrosis factor receptor (TNFR) superfamily and mediates cell death in various cell types. A dual mode of Fas-triggered cell death has been reported depending on cell types used in the experiments. The present study was carried out to test the possible role of reactive oxygen species in this dual mechanism in neuroglioma cells. Anti-Fas antibody caused dose-dependent and time-dependent increase in cell death measured by lactate dehydrogenase (LDH) release in… CONTINUE READING