Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors.

@article{Lorendeau2017DualLO,
  title={Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors.},
  author={Doriane Lorendeau and Gianmarco Rinaldi and Ruben Boon and Pieter Spincemaille and Kristine Metzger and Christian Jaeger and Stephan Christen and Xiangyi Dong and Sabine Kuenen and Karin Voordeckers and Patrik Verstreken and David M Cassiman and Pieter Vermeersch and Catherine M. Verfaillie and Karsten Hiller and Sarah-Maria Fendt},
  journal={Metabolic engineering},
  year={2017},
  volume={43 Pt B},
  pages={
          187-197
        }
}
Mutations in succinate dehydrogenase (SDH) are associated with tumor development and neurodegenerative diseases. Only in tumors, loss of SDH activity is accompanied with the loss of complex I activity. Yet, it remains unknown whether the metabolic phenotype of SDH mutant tumors is driven by loss of complex I function, and whether this contributes to the peculiarity of tumor development versus neurodegeneration. We addressed this question by decoupling loss of SDH and complex I activity in… CONTINUE READING
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