Dual isotope Schilling test for measuring absorption of food-bound and free vitamin B12 simultaneously.

@article{Doscherholmen1983DualIS,
  title={Dual isotope Schilling test for measuring absorption of food-bound and free vitamin B12 simultaneously.},
  author={Alfred Doscherholmen and Stephen E. Silvis and J. W. Mcmahon},
  journal={American journal of clinical pathology},
  year={1983},
  volume={80 4},
  pages={
          490-5
        }
}
A prototype food-bound vitamin B12 (food-B12) absorption test has been developed in which 57Co-B12 was incorporated in vitro into egg yolk (yolk-B12) and served to volunteers in 50-g cooked portions together with toast and coffee for breakfast. Six hours later, 1 mg nonlabeled B12 was given intramuscularly and 24-hour urine was collected for radioactivity measurement. In separate tests, the absorption of yolk-B12 and crystalline 57Co-B12 was equally poor in patients with pernicious anemia… CONTINUE READING
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