Dual interaction of the Hsp70 J protein co-chaperone Zuotin with the 40S and 60S subunits of the ribosome

@inproceedings{Lee2016DualIO,
  title={Dual interaction of the Hsp70 J protein co-chaperone Zuotin with the 40S and 60S subunits of the ribosome},
  author={Kanghyun Lee and R Sharma and Om Kumar Shrestha and Craig A. Bingman and Elizabeth A Craig},
  booktitle={Nature Structural &Molecular Biology},
  year={2016}
}
Ribosome-associated J protein–Hsp70 chaperones promote nascent-polypeptide folding and normal translational fidelity. The J protein Zuo1 is known to span the ribosomal subunits, but understanding of its function is limited. Here we present new structural and cross-linking data allowing more precise positioning of Saccharomyces cerevisiae Zuo1 near the 60S polypeptide-exit site and suggesting interactions of Zuo1 with the ribosomal protein eL31 and 25S rRNA helix 24. The junction between the 60S… CONTINUE READING