Dual inhibitory effects of APOBEC family proteins on retrotransposition of mammalian endogenous retroviruses

@article{Esnault2006DualIE,
  title={Dual inhibitory effects of APOBEC family proteins on retrotransposition of mammalian endogenous retroviruses},
  author={C{\'e}cile Esnault and Jean Kaoru Millet and Olivier Schwartz and T. Heidmann},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={1522 - 1531}
}
We demonstrated previously that the cytosine deaminase APOBEC3G inhibits retrotransposition of two active murine endogenous retroviruses, namely intracisternal A-particles (IAP) and MusD, in an ex vivo assay where retrotransposition was monitored by selection of neo-marked elements. Sequencing of the transposed copies further disclosed extensive editing, resulting in a high load of G-to-A mutations. Here, we asked whether this G-to-A editing was associated with an impact of APOBEC3G on viral… CONTINUE READING

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