Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors.

@article{Salvemini1995DualIO,
  title={Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors.},
  author={Daniela Salvemini and Pamela T. Manning and Ben S. Zweifel and Karen Seibert and Jerome Connor and Mark G. Currie and Philip Needleman and Jaime L. Masferrer},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={96 1},
  pages={
          301-8
        }
}
We have recently put forward the hypothesis that the dual inhibition of proinflammatory nitric oxide (NO) and prostaglandins (PG) may contribute to the antiinflammatory properties of nitric oxide synthase (NOS) inhibitors. This hypothesis was tested in the present study. A rapid inflammatory response characterized by edema, high levels of nitrites (NO2-, a breakdown product of NO), PG, and cellular infiltration into a fluid exudate was induced by the administration of carrageenan into the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 95 CITATIONS, ESTIMATED 61% COVERAGE

Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications.

  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2013
VIEW 4 EXCERPTS
CITES BACKGROUND

Nitric oxide synthase isoforms and glomerular hyperfiltration in early diabetic nephropathy.

  • Journal of the American Society of Nephrology : JASN
  • 2000
VIEW 18 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1996
2017

CITATION STATISTICS

  • 2 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 32 REFERENCES

Nitric oxide activates cyclooxygenase enzymes.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1993
VIEW 5 EXCERPTS

Evidence for nitric oxide induction of cyclooxygenase-l activity by hemeindependent mechanisms

D. P. Hajjar, H. M. Lander, S.A.F. Pearce, K. B. Pomerantz
  • FASEB (Fed. Am. Soc. Exp. Biol.) J. l0:A1432
  • 1994
VIEW 3 EXCERPTS

In vivo regulation of cyclooxygenase-2 but not cyclooxygenase-1 by glucocorticoids in peritoneal macrophages

J. L. Masferrer, S. T. Reddy, +3 authors H. R. Herschman
  • J. Pharmacol. Exp. Ther
  • 1994
VIEW 1 EXCERPT

Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1994
VIEW 1 EXCERPT