Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors.

@article{Salvemini1995DualIO,
  title={Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors.},
  author={Daniela Salvemini and Pamela T. Manning and Ben Scott Zweifel and Karen Seibert and Jerome Connor and Mark G. Currie and Philip Needleman and Jaime L. Masferrer},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={96 1},
  pages={301-8}
}
We have recently put forward the hypothesis that the dual inhibition of proinflammatory nitric oxide (NO) and prostaglandins (PG) may contribute to the antiinflammatory properties of nitric oxide synthase (NOS) inhibitors. This hypothesis was tested in the present study. A rapid inflammatory response characterized by edema, high levels of nitrites (NO2-, a breakdown product of NO), PG, and cellular infiltration into a fluid exudate was induced by the administration of carrageenan into the… CONTINUE READING
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