Dual inhibition of human rhinovirus 2A and 3C proteases by homophthalimides.

  title={Dual inhibition of human rhinovirus 2A and 3C proteases by homophthalimides.},
  author={Q. May Wang and Robert B. Johnson and Louis N Jungheim and Jerry D. Cohen and Enrique Cervantes Villarreal},
  journal={Antimicrobial agents and chemotherapy},
  volume={42 4},
The 2A and 3C proteases encoded by human rhinoviruses (HRVs) are attractive targets for antiviral drug development due to their important roles in viral replication. Homophthalimides were originally identified as inhibitors of rhinovirus 3C protease through our screening effort. Previous studies have indicated that the antiviral activity of certain homophthalimides exceeded their in vitro inhibitory activity against the viral 3C protease, suggesting that an additional mechanism might be… CONTINUE READING

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