Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.

@article{Marrs2011DualIO,
  title={Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.},
  author={William R. Marrs and Eric A. Horne and Silvia Ortega-Guti{\'e}rrez and Jos{\'e} Antonio Cisneros and Cong Xu and Yi Hsing Lin and Giulio G Muccioli and Mar{\'i}a L. L{\'o}pez-Rodr{\'i}guez and Nephi Stella},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 33},
  pages={
          28723-8
        }
}
Agonists at cannabinoid receptors, such as the phytocannabinoid Δ(9)-tetrahydrocannabinol, exert a remarkable array of therapeutic effects but are also associated with undesirable psychoactive side effects. Conversely, targeting enzymes that hydrolyze endocannabinoids (eCBs) allows for more precise fine-tuning of cannabinoid receptor signaling, thus providing therapeutic relief with reduced side effects. Here, we report the development and characterization of an inhibitor of eCB hydrolysis… CONTINUE READING
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