Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro.

@article{Che2016DualIO,
  title={Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro.},
  author={Xiao-Hang Che and Chun-Lin Chen and Xiao-lei Ye and Guo-bin Weng and Xian-zhi Guo and Wen-Ying Yu and Jin Tao and Yi-Chen Chen and Xiaodong Chen},
  journal={Oncology reports},
  year={2016},
  volume={35 3},
  pages={1680-8}
}
Inflammation is emerging as a new hallmark of cancer. Arachidonic acid (AA) metabolism, the family of cyclooxygenases (COXs) and lipoxygenase (LOX) play important roles in AA-related inflammatory cascades. In 94 colorectal cancer samples collected from the Han population, the immunohistochemical results indicated that 68% of the patients with colorectal cancer had a co-expression of both COX-2 and 5-LOX, while both displayed low expression in the matched normal tissues. In cell lines, three… CONTINUE READING
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Microbes , microbiota , and colon cancer

  • B Magalhães, B Peleteiro, N Lunet
  • Cell Host Microbe
  • 2014

Effect of liposomal celecoxib on proliferation of colon cancer cell and inhibition of DMBA - induced tumor in rat model

  • S Tavolari, A Munarini, G Storci, S Laufer, P Chieco, T Guarnieri
  • Cancer Nanotechnol
  • 2011

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