Dual impairment of GABAA- and GABAB-receptor-mediated synaptic responses by autoantibodies to glutamic acid decarboxylase.

@article{Mitoma2003DualIO,
  title={Dual impairment of GABAA- and GABAB-receptor-mediated synaptic responses by autoantibodies to glutamic acid decarboxylase.},
  author={Hiroshi Mitoma and Kazuyuki Ishida and Masami Shizuka-Ikeda and Hidehiro Mizusawa},
  journal={Journal of the neurological sciences},
  year={2003},
  volume={208 1-2},
  pages={51-6}
}
Anti-glutamate decarboxylase autoantibodies (GAD-A) are associated with a group of patients with progressive cerebellar ataxia. We reported previously that cerebellar GABA(A)-mediated synaptic transmission was presynaptically depressed by GAD-A in the cerebrospinal fluid (CSF). Using whole-cell recording of rat cerebellar slices, we found in the present study that CSF immunoglobulins from ataxic patients reduced gamma-aminobutyric acid (GABA) release from cerebellar interneurons, thereby… CONTINUE READING
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