Dual immunoregulatory effects of monoclonal IgG-antibodies: suppression and enhancement of the antibody response.

@article{Wiersma1989DualIE,
  title={Dual immunoregulatory effects of monoclonal IgG-antibodies: suppression and enhancement of the antibody response.},
  author={Erik J. Wiersma and Pierre G Coulie and B Heyman},
  journal={Scandinavian journal of immunology},
  year={1989},
  volume={29 4},
  pages={
          439-48
        }
}
Nine monoclonal IgG-anti-TNP antibodies were investigated for their ability to modulate anticarrier responses in mice immunized with sheep red blood cells-2,4,6-trinitrophenyl (SRBC-TNP) or keyhole limpet haemocyanin-TNP (KLH-TNP). The antibodies enhanced the anticarrier response when KLH-TNP was used as antigen but suppressed it when SRBC-TNP was used. The enhancing and suppressive effects were not exerted by entirely the same sets of antibodies. The suppression was correlated to efficient… CONTINUE READING
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