Dual functions of thyroid hormone receptors during Xenopus development.

  title={Dual functions of thyroid hormone receptors during Xenopus development.},
  author={Laurent M. Sachs and Sashko Damjanovski and Peter Lloyd Jones and Qing Li and Tosikazu Amano and Shuichi Ueda and Yanbo Shi and Atsuko Ishizuya-Oka},
  journal={Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology},
  volume={126 2},
Thyroid hormone (TH) plays a causative role in anuran metamorphosis. This effect is presumed to be manifested through the regulation of gene expression by TH receptors (TRs). TRs can act as both activators and repressors of a TH-inducible gene depending upon the presence and absence of TH, respectively. We have been investigating the roles of TRs during Xenopus laevis development, including premetamorphic and metamorphosing stages. In this review, we summarize some of the studies on the TRs by… CONTINUE READING