Dual functions of a monoclonal antibody against cell surface F1F0 ATP synthase on both HUVEC and tumor cells

@article{Zhang2008DualFO,
  title={Dual functions of a monoclonal antibody against cell surface F1F0 ATP synthase on both HUVEC and tumor cells},
  author={Xia Zhang and Feng Gao and Li-li Yu and Yan Peng and Hong-hai Liu and Jin-Ying Liu and Ming Yin and Jian Ni},
  journal={Acta Pharmacologica Sinica},
  year={2008},
  volume={29},
  pages={942-950}
}
AbstractAim:To generate a monoclonal antibody (McAb) against cell surface F1F0 ATP synthase (ATPase) and observe its antitumoral activity on both human umbilical vein endothelial cells (HUVEC) and tumor cells.Methods:Hybridoma cells secreting McAb against ATPase were produced by polyethylene glycol-mediated fusions and screened by ELISA. The specificity of McAb was demonstrated by immunofluorescence and confocal imaging, as well as flow cytometry analysis. After the blockade of surface ATPase… CONTINUE READING

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