Dual functions, clamp opening and primer-template recognition, define a key clamp loader subunit.

@article{Coman2004DualFC,
  title={Dual functions, clamp opening and primer-template recognition, define a key clamp loader subunit.},
  author={Maria Magdalena Coman and Mi Young Jin and Razvan Ceapa and Jeff Finkelstein and Michael R O'Donnell and Brian T Chait and Manju M Hingorani},
  journal={Journal of molecular biology},
  year={2004},
  volume={342 5},
  pages={1457-69}
}
Clamp loader proteins catalyze assembly of circular sliding clamps on DNA to enable processive DNA replication. During the reaction, the clamp loader binds primer-template DNA and positions it in the center of a clamp to form a topological link between the two. Clamp loaders are multi-protein complexes, such as the five protein Escherichia coli, Saccharomyces cerevisiae, and human clamp loaders, and the two protein Pyrococcus furiosus and Methanobacterium thermoautotrophicum clamp loaders, and… CONTINUE READING
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